References
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Our completed projects and successful studies
Roxadustat alleviates metabolic traits in letrozole-induced PCOS mice. Virtanen N, Saarela U, Karpale M, Arffman RK, Mäkelä KA, Herzig KH, Koivunen P, Piltonen T. Biochem Pharmacol. 2024 Nov;229:116522.
Sortilin‐related receptor is a druggable therapeutic target in breast cancer. MedRod® implants in the Orthotopic in vivo xenografts. Al-Akhrass H, Pietilä M, Lilja J, et al. Mol Oncol. 2022;16(1):116-129.
Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models. Hammer S, Schlicker A, Zitzmann-Kolbe S, et al. Clin Cancer Res. 2021;27(15):4367-4378.
Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model. Cancer Lett. 2021 Jun 28;508:18-29 .
Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure. Gonda FJ Konings, Niina Saarinen, Bert Delvoux, Loes Kooreman, Pasi Koskimies, Camilla Krakstad, Kristine E. Fasmer, Ingfrid S. Haldorsen, Amina Zaffagnini, Merja R. Häkkinen, Seppo Auriola, Ludwig Dubois, Natasja Lieuwes, Frank Verhaegen, Lotte EJR Schyns, Roy FPM Kruitwagen, ENITEC Consortium, Sofia Xanthoulea and Andrea Romano. Int J Mol Sci. 2018 Aug 28;19(9).
More References
Importance of estradiol dosing method in mouse models of ER+ breast cancer. Jukka Rissanen, Leila Koskela, Niina Saarinen-Aaltonen, Merja Häkkinen, Seppo Auriola, Harri Jukarainen and Saku Ruohonen. 31st International Association for Breast Cancer Research Conference (IABCR 2019).
Characterization of Tumor Growth Supported by Novel Dihydrotestosterone Releasing Implants in a Subcutaneous Prostate Cancer Xenograft Model. Pharmatest poster at ScandLas annual meeting 2018.
Importance of Tumor Microenvironment in the Preclinical Estrogen Receptor Positive Breast Cancer — Primary Tumor and Bone Metastasis Models. Pharmatest minisymposium at AACR meeting 2017.
Estrogen induces severe urinary tract defects – a strain dependent difference in nude vs NOG female mice. Pharmatest presentation at ScandLas meeting 2017.
Novel long term substance delivery method in preclinical osteoporosis studies. Rissanen JP, Ruohonen ST, Jukarainen H. Osteoporos Int. 2016 April; 27 (1) supplement.
Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices. Genina N, Holländer J, Jukarainen H, Mäkilä E, Salonen J, Sandler N. Eur J Pharm Sci. 2015 Nov 3.
Drug implants, technology serving delivery. Jukarainen H, Strömberg C. Duodecim.2004;120(16):2008-14. Review.
Novel delivery systems in contraception. Lähteenmäki P, Jukarainen H. Br Med Bull. 2000 56(3):739-48. Review.
Importance of estradiol dosing method in mouse models of ER+ breast cancer. Jukka Rissanen, Leila Koskela, Niina Saarinen-Aaltonen, Merja Häkkinen, Seppo Auriola, Harri Jukarainen and Saku Ruohonen. 31st International Association for Breast Cancer Research Conference (IABCR 2019). IABCR 2019_Preclinapps.pdf
Characterization of Tumor Growth Supported by Novel Dihydrotestosterone Releasing Implants in a Subcutaneous Prostate Cancer Xenograft Model. Pharmatest poster at ScandLas annual meeting 2018. Pharmatest poster LNCaP sc ScandLAS 2018.pdf